Evaluation of immunomodulatory activities of methanolic extract of khat (Catha edulis, Forsk) and cathinone in Swiss albino mice
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منابع مشابه
Effect of chronic khat (Catha edulis, Forsk) use on outcome of Plasmodium berghei ANKA infection in Swiss albino mice
BACKGROUND The objective of this study was to explore effects of khat (Catha edulis) on outcome of rodent malaria infection and its anti-plasmodial activities on Plasmodium berghei ANKA (PbA). METHODS Female Swiss albino mice were orally treated with crude khat (Catha edulis) extracts (100, 200 and 300 mg/kg) on a daily basis for 4 weeks prior to PbA infection. Physical, clinical, hematologic...
متن کاملCatha edulis Forsk. (Khat): Evaluation of its Antidepressant-like Activity
BACKGROUND Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. OBJECTIVE Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. MATERIALS AND ME...
متن کاملSubchronic oral administration of crude khat extract (Catha edulis forsk) induces schizophernic-like symptoms in mice
BACKGROUND Chewing fresh leaves of the khat plant (Catha edulis forsk) is a deep rooted and widespread habit in East Africa and the Middle East. Although a body of knowledge exists about the adverse effects of khat on health, data are sparse with regard to the consequences of long-term khat chewing in resulting schizophrenic like symptoms. METHODS A crude extract of khat at different doses (1...
متن کاملAssessment of khat (Catha edulis Forsk) 1. Substance Identification
F. WHO Review History: The WHO Expert Committee on Drug Dependence (ECDD) and other UN bodies reviewed khat at earlier occasions. The Advisory Committee on the Traffic in Opium and Other Dangerous Drugs of the League of Nations discussed on the subject in 1933, but no action was taken. On request of the Commission on Narcotics Drugs (CND), the Expert Committee on Addiction-Producing Drugs (as t...
متن کاملIn vitro hepatotoxcity of Catha edulis Forsk. (khat) phenolic-rich extract on human hepatocytes
Article history: Received on: 09/12/2013 Revised on: 18/01/2014 Accepted on: 03/03/2014 Available online: 27/11/2014 In our previous research, Khat has been shown to be associated with hepatic hypertrophy and hepatotoxicity in male and female SD-rats. However, no in vitro studies have been previously done to test on hepatotoxicity of khat on human experimental models. In vitro toxicological eva...
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ژورنال
عنوان ژورنال: BMC Immunology
سال: 2015
ISSN: 1471-2172
DOI: 10.1186/s12865-015-0072-5